SKU: 25990653291

Human CD33, His tag

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Description

Human CD33, His tagProduct Specification Species Human Synonyms Sialic acid binding Ig like lectin 3 (Siglec 3), gp67 Accession P20138 Amino Acid Sequence Protein sequence(P20138, Asp18 His259, with C 10*His) DPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGGGGSHHHHHHHHHH

Product Specification


Species Human
Synonyms Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67
Accession P20138
Amino Acid Sequence

Protein sequence(P20138, Asp18-His259, with C-10*His)
DPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGGGGSHHHHHHHHHH
Expression System HEK293
Molecular Weight Theoretical: 28.5kDa Actual: 45kDa
Purity

＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 ℃ to -70 °C as supplied. 1 month,

2 to 8 °C under sterile conditions after reconstitution.  

Please avoid repeated freeze-thaw cycles. 

Background

CD33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. The level of CD33 was found to be increased in the AD brain, which positively correlated with amyloid plaque burden and disease severity. More importantly, CD33 led to the impairment of microglia-mediated clearance of Aβ, which resulted in the formation of amyloid plaques in the brain.

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Exchange/Return Notes
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SKU: 25990653291

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4.7 ★★★★★
Based on 1473 reviews
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Product Reviews
S
Verified Purchase
Scott L.
West Palm Beach, US
★★★★★ 5
Good fun and entertaining!
Color: Orange
A really fun interactive toy for your dog! It's pretty erratic and really gets him chasing it. The included soft cover was kinda hard to install and then it's hard to turn it off and on with the cover on, I feel like the cover didn't really improve it at all, sure it's louder without the cover but I feel like dog also likes it that way, he likes loud squeaky toys and this thing making a bunch of noise is appealing to him. We have mostly hardwood floors so it really gets moving, I'm sure on carpet it would be a bit quieter and maybe even a bit slower to move around but on hard smooth surfaces this things can really get zipping around abd get some speed to make him chase it. Overall a fun and entertaining toy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 27, 2026
B
Verified Purchase
bill a.
Carnegie, US
★★★★★ 5
Awesome
Color: Orange
Awesome Toy . My Jack is crazy over it. She usually get bored with others, but this toy still has her attention after a couple of weeks Runs a long time on a short charge. 👍🏻
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Reviewed in the United States on May 30, 2026
C
Verified Purchase
Chad
Waukegan, US
★★★★★ 2
Not the Fetch-Fest I Hoped For
Color: Orange
I had high hopes for the PetDroid Interactive Dog Ball, especially with the newly upgraded features and promises of durable, motion-activated fun. Unfortunately, it didn’t quite live up to expectations for my furry friend. Here’s why I’m giving it 2 stars. Promising Features, Lackluster Results The idea behind this toy is fantastic: a durable, motion-activated ball that would entertain my dog without much effort on my part. The ball is supposed to roll around on its own, keeping my dog engaged and active. However, in practice, it just didn’t capture my dog’s interest. Durability I will give credit where it’s due: the ball is well-made and seems durable. It can withstand some rough handling, which is great for more aggressive chewers. Unfortunately, durability doesn’t mean much if your dog won’t play with it in the first place. Motion Activation The motion activation feature is hit or miss. While the ball does move around as advertised, it didn’t seem to move in a way that intrigued my dog. He gave it a sniff, watched it for a minute, and then walked away, unimpressed. I tried multiple times to get him interested, but he simply wasn’t having it. Lack of Engagement The biggest issue is that the ball just didn’t engage my dog at all. It might be more suitable for a different personality type or breed, but for my pooch, it was a total flop. He’s usually quite playful and curious, so I was surprised by his lack of interest. Final Thoughts Overall, the PetDroid Interactive Dog Ball might work for some dogs, but it was a miss for mine. If your dog is easily entertained by automated toys, it might be worth a try. However, based on my experience, I can’t wholeheartedly recommend it. Pros: Durable construction Motion-activated as advertised Cons: Did not engage my dog Motion activation wasn’t intriguing enough Might be more suitable for specific dog types or personalities If you decide to give it a shot, just be prepared for the possibility that your dog might not find it as entertaining as you hope. For us, it’s back to the drawing board for a more engaging toy.
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Reviewed in the United States on June 14, 2024
S
Verified Purchase
Sally
Lake Worth, US
★★★★★ 4
Pup Loves It, Some Other Notes
Color: Orange
We've had this for about six months and my 75 lb, 14-month-old German Shepherd pup LOVES IT. Her favorite is "Crazy Bouncing Mode." In fact, she doesn't care much for the normal mode. She chews it a lot - even drops it in her water bowl at times - and it's still going strong. This is a great purchase. It's nice hands-off entertainment. Do know that it is heavy compared to a normal ball - if your pup likes dropping it on the ground like mine does, it will land with a hard "thud," even with the included sleeve. Hopefully you don't have downstairs neighbors. Also know that the cover that goes over the charging port is removable and your dog may choke on it if they chew it in just the right manner. Definitely only let the pup play with it while supervised. All in all, great toy.
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Reviewed in the United States on February 11, 2026
M
Verified Purchase
Michelle
Port Orchard, US
★★★★★ 5
Fun toy that is tough!
Pattern Name: Cage Ball, Size: Large - 4 Inch / 8.5 oz
This is a great ball that my dog loves and he has not destroyed it!k
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Reviewed in the United States on March 13, 2026

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