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Description
Phospho-MLKL (Ser358) Recombinant Rabbit mAb (S-4248)Product Specification Host Rabbit Antigen MLKL Synonyms Mixed lineage kinase domain like protein; hMLKL; MLKL Location Cytoplasm, Nucleus, Cell membrane Accession Q8NB16 Clone Number S 4248 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample Z VAD, hTNF and SM 164 treated HT 29 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%
Product Specification
| Host | Rabbit |
| Antigen | MLKL |
| Synonyms | Mixed lineage kinase domain-like protein; hMLKL; MLKL |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q8NB16 |
| Clone Number | S-4248 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Z-VAD, hTNF-α and SM-164 treated HT-29 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that belongs to the protein kinase superfamily and contains a protein kinase-like domain but lacks catalytic activity. It plays a crucial role in necroptosis, a form of regulated cell death. When activated by receptor-interacting protein kinase 3 (RIPK3), MLKL oligomerizes and translocates to the plasma membrane, causing membrane permeabilization and ultimately leading to cell death. Besides its canonical role in necroptosis, MLKL has been found to be associated with various cellular organelles, such as the mitochondrion, lysosome, endosome, endoplasmic reticulum, and nucleus, where it may regulate diverse pathophysiological events. Additionally, MLKL has necroptosis-independent functions in processes like receptor internalization, ligand-receptor degradation, endosomal trafficking, autophagy, and nuclear functions. Its involvement in multiple diseases and potential as a therapeutic target are also being actively investigated.
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